T-cell homeostasis: the dark(ened) side of common variable immunodeficiency.

عوارض ناشی از تزریق ایمونوگلوبولین وریدی در بیماران با نقص ایمنی اولیه

Background and Purpose: Intravenous immunoglobulin is used for primary immunodeficiency disorders. There have been some reports that intravenous immunoglobulin causes side effects. The aim of this study was to investigate intravenous immunoglobulin side effects in immunodeficiency patients. Materials and Methods: The study utilized the data of 29 primary immunodeficiency patients that were...

A CASE REPORT OF COMMON VARIABLE IMMUNODEFICIENCY(CV ID) WITH LEUKOCYTES ADHESION DISORDERS (LADS)

A three year old boy with delayed separation of the umbilical cord, recurrent pyogenic infections and common variable immundeficiency is presented. The immunoglobulin measurement was severely abnormal. To the best of our knowledge, the existance of leukocyte adhesion disorder together with common variable immunodeficiency (CYID) in a patient has not been reported prior to this study.

CLINICAL TRIALS AND OBSERVATIONS Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency

The homozygous deletion of the inducible costimulator (ICOS), an activationinduced member of the CD28 family on T cells, causes an antibody deficiency syndrome in affected humans. The identification of a total of 9 ICOS-deficient patients revealed that this monogenic disease comprises the full clinical phenotype described for common variable immunodeficiency (CVID), including recurrent bacteria...

A 20-YEAR SURVEY OF INFECTIOUS COMPLICATIONS IN 64 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

Common variable immunodeficiency (CV ID) is a heterogeneous primary immunodeficiency disorder, characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. To determine the spectrum of infectious complications in patients with common variable immunodeficiency (CV ID), we reviewed the hospital records of 64 CVID patients, who were diagnosed in Child...

Co-existence of Common Variable Immunodeficiency (CVID) with Idiopathic Thrombocytopenic purpura (ITP)